- Joining the Immunological Dots in Recurrent Miscarriage
- Th1:Th2 cytokines profiles in IVF
- Prednisolone suppresses NK cell cytotoxicity in vitro
- Cytokines and NK cells in IVF
- The effect of leukaemia inhibitory factor on in IVF outcome
- Simple enumeration of lymphocyte subsets have no predictive value in IVF treatment outcome
- Activated NK cells have predictive value in IVF outcome
- Elevated Levels of Serum Vascular Endothelial Growth Factor-A
- Human chorionic gonadotropin
- Mechanism of human chorionic gonadotrophin-mediated immunomodulation in pregnancy
- The basis and value of currently used immunomodulatory therapies in recurrent miscarriage
- Recurrent miscarriage and automimmunity
Research & Development
RIC strongly believes in an active R&D programme, leading to publication and a better understanding of the role of the immune system in infertility and pregnancy. To this end, we collaborate with leading fertility clinics and publish our findings in peer reviewed journals. We also fund research into developing new and better assays with a view to improving diagnosis and therapy of infertility.
Joining the Immunological Dots in Recurrent Miscarriage.
Bansal AS.
Am J Reprod Immunol. Nov 2010; 64(5):307-31
Download the full abstract here
Serial estimation of Th1:th2 cytokines profile in women undergoing in-vitro fertilization-embryo transfer.
Kalu E, Bhaskaran S, Thum MY, Vishwanatha R, Croucher C, Sherriff E, Ford B, Bansal AS.
Am J Reprod Immunol. 2008 Mar;59(3):206-11.
Download the full abstract here
Prednisolone suppresses NK cell cytotoxicity in vitro in women with a history of infertility and elevated NK cell cytotoxicity.
Thum MY, Bhaskaran S, Abdalla HI, Ford B, Sumar N, Bansal A.
Am J Reprod Immunol. 2008 Mar;59(3):259-65.
Download the full abstract here
The relationship of systemic TNF-alpha and IFN-gamma with IVF treatment outcome and peripheral blood NK cells.
Thum MY, Abdalla HI, Bhaskaran S, Harden EL, Ford B, Sumar N, Shehata H, Bansal A.
Am J Reprod Immunol. (2007) 57(3):210-7.
Download the full abstract here
The effect of serum concentration of leukaemia inhibitory factor on in vitro fertilization treatment outcome.
Thum MY, Abdalla HI, Bhaskaran S, Harden EL, Ford B, Sumar N, Shehata H, Bansal AS
Am J Reprod Immunol. 2006 Jan;55(1):76-80.
Download the full abstract here
Simple enumerations of peripheral blood natural killer (CD56+ NK) cells, B cells and T cells have no predictive value in IVF treatment outcome.
Thum MY, Bhaskaran S, Bansal AS, Shehata H, Ford B, Sumar N, Abdalla HI.
Hum Reprod. 2005 May;20(5):1272-6.
Download the full case study here
An increase in the absolute count of CD56dimCD16+CD69+ NK cells in the peripheral blood is associated with a poorer IVF treatment and pregnancy outcome.
Thum MY, Bhaskaran S, Abdalla HI, Ford B, Sumar N, Shehata H, Bansal AS.
Hum Reprod. Oct 2004;19(10):2395-400.
Download the full case study here
Elevated Levels of Serum Vascular Endothelial Growth Factor-A Are Not Related to NK Cell Parameters in Recurrent IVF Failure.
Bansal R, Ford B, Bhaskaran S, Thum M, Bansal A.
J Reprod Infertil.
2017 Jul-Sep;18(3):280-287.
Human chorionic gonadotropin – can nature’s own antirejection agent help in reducing chronic rejection in solid organ transplantation?
Bansal AS.
Reproductive Immunol Open Acc.
2016, 1:1. doi: 10.4172/2476-1974.100001
Mechanism of human chorionic gonadotrophin-mediated immunomodulation in pregnancy.
Bansal AS1, Bora SA, Saso S, Smith JR, Johnson MR, Thum MY.
Expert Rev Clin Immunol
2012 Nov;8(8): 747-53.doi: 10 1586/eci. 12.77.
The basis and value of currently used immunomodulatory therapies in recurrent miscarriage.
Bansal AS, Bajardeen B, Thum MY.
J Reprod Immunol.
2012 Jan;93(1):41-51. doi: 10.1016/j.jri.2011.10.002. Epub 2011 Dec 21. Review.
Recurrent miscarriage and automimmunity.
Bansal AS, Bajardeen B, Shehata H, Thum MY.
Expert Rev Clin Immunol.
2011 Jan;7(1):37-44. doi: 10.1586/eci.10.84. Review.
RIC is presently researching the role of VEGF and NK cells in early reproductive failure and refining the protocols on when, how much and in whom immune modulatory therapy with IVIg, steroids and intralipid should be used. We are also working on peripheral steroid resistance which may reduce the efficacy of steroids to downregulate excessive NK cell activity that is a barrier for women to conceive and give birth. Finally we are in the early phase of work on maternal autoimmunity against the folate receptor that has been shown to increase the risk of certain conditions in babies and children.